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Protomer A of WT Mpro is coloured white and protomer B of WT Mpro is coloured black, nirmatrelvir in WT Mpro-nirmatrelvir intricate structure is demonstrated as inexperienced sticks, protomer A in the mutant composition is colored marine and protomer B with the mutant construction is coloured orange, nirmatrelvir in mutant Mpro-nirmatrelvir advan